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A knife in an enchilada was the oddest thing the TSA seized in 2014

Homeland Security News - Sat, 01/24/2015 - 12:35

2014 was a big year for people forgetting about guns in their luggage. In fact, according to information on contraband that the TSA just released in its year in review, the number of firearms confiscated by the TSA hit a record high of 2,212 — a 22% increase from 2013 to 2014. Unloaded guns are […]

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A knife in an enchilada was the oddest thing the TSA seized in 2014

Categories: Homeland Security News

Denver woman who tried to help terrorists receives 4 years

Homeland Security News - Sat, 01/24/2015 - 12:27

A 19-year-old suburban Denver woman who tried to go to Syria to help Islamic State militants was sentenced to four years in prison Friday, even as she tearfully told a judge that she never wanted to hurt anyone and has disavowed jihad. Shannon Conley told the judge she was misled while pursuing Islam and learned […]

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Denver woman who tried to help terrorists receives 4 years

Categories: Homeland Security News

Sleeper Cells: The Immigration Component of the Threat

Homeland Security News - Sat, 01/24/2015 - 12:17

In the wake of the terror attacks in Paris, France terror raids were carried out in Belgium and Greece to identify, locate and hunt down so-called “sleepers cells.” Journalists and politicians have finally raised the issue of the threats potentially posed by sleeper agents in the United States, going back to the future — the […]

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Sleeper Cells: The Immigration Component of the Threat

Categories: Homeland Security News

Spanish police arrest 4 suspected members of a jihadi cell

Homeland Security News - Sat, 01/24/2015 - 12:05

Spanish National Police arrested four suspected jihadis Saturday in the country’s North African enclave of Ceuta who allegedly had formed a terror cell and were ready to carry out an attack, the Interior Ministry said. Interior Minister Jorge Fernandez Diaz said investigators, working with their Moroccan counterparts, were struck by the similarities between the suspected […]

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Spanish police arrest 4 suspected members of a jihadi cell

Categories: Homeland Security News

Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid.

Jeffrey D. Laskin, Ph.D. - Fri, 01/23/2015 - 15:00

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Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid.

Free Radic Biol Med. 2014 Feb;67:1-9

Authors: Zheng R, Heck DE, Black AT, Gow A, Laskin DL, Laskin JD

Abstract
Nitric oxide and various by-products including nitrite contribute to tissue injury by forming novel intermediates via redox-mediated nitration reactions. Nitration of unsaturated fatty acids generates electrophilic nitrofatty acids such as 9-nitrooleic acid (9-NO) and 10-nitrooleic acid (10-NO), which are known to initiate intracellular signaling pathways. In these studies, we characterized nitrofatty acid-induced signaling and stress protein expression in mouse keratinocytes. Treatment of keratinocytes with 5-25μM 9-NO or 10-NO for 6h upregulated mRNA expression of heat shock proteins (hsp's) 27 and 70; primary antioxidants heme oxygenase-1 (HO-1) and catalase; secondary antioxidants glutathione S-transferase (GST) A1/2, GSTA3, and GSTA4; and Cox-2, a key enzyme in prostaglandin biosynthesis. The greatest responses were evident with HO-1, hsp27, and hsp70. In keratinocytes, 9-NO activated JNK and p38 MAP kinases. JNK inhibition suppressed 9-NO-induced HO-1, hsp27, and hsp70 mRNA and protein expression, whereas p38 MAP kinase inhibition suppressed HO-1. In contrast, inhibition of constitutive expression of Erk1/2 suppressed only hsp70, indicating that 9-NO modulates expression of stress proteins by distinct mechanisms. 9-NO and 10-NO also upregulated expression of caveolin-1, the major structural component of caveolae. Western blot analysis of caveolar membrane fractions isolated by sucrose density centrifugation revealed that HO-1, hsp27, and hsp70 were localized within caveolae after nitrofatty acid treatment of keratinocytes, suggesting a link between induction of stress response proteins and caveolin-1 expression. These data indicate that nitrofatty acids are effective signaling molecules in keratinocytes. Moreover, caveolae seem to be important in the localization of stress proteins in response to nitrofatty acids.

PMID: 24140437 [PubMed - indexed for MEDLINE]

Categories: Publications from UCDPER Members

Drone loaded with meth crashes near US-Mexico border crossing

Homeland Security News - Thu, 01/22/2015 - 23:05

Police in a Mexican border city said Wednesday that a drone overloaded with illicit methamphetamine crashed into a supermarket parking lot. Tijuana police spokesman Jorge Morrua said authorities were alerted after the drone fell Tuesday night near the San Ysidro crossing at Mexico’s border with California. Read More This story comes to us via Homeland […]

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Drone loaded with meth crashes near US-Mexico border crossing

Categories: Homeland Security News

UK warned of ‘very significant risk’ of ISIS-inspired terror attack

Homeland Security News - Thu, 01/22/2015 - 23:01

Britain is at ‘very significant risk’ from a terror attack by extremists inspired by ISIS jihadis, Foreign Secretary Philip Hammond warned today. Speaking ahead of a counter-terror summit in London today, he warned against complacency in the fight to ‘disrupt these plots before they come to the stage of an attack’. As foreign ministers from […]

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UK warned of ‘very significant risk’ of ISIS-inspired terror attack

Categories: Homeland Security News

Saudi Arabia’s ‘reformer’ King Abdullah dies

Homeland Security News - Thu, 01/22/2015 - 22:55

Throngs of mourners gathered in Mecca early Friday just hours after Saudi Arabia’s King Abdullah bin Abdulaziz al Saud died. He was 90. Prince Salman bin Abdulaziz was appointed as the new king, state television reported. The announcement of Abdullah’s death comes several weeks after the state-run Saudi Press Agency said he was suffering from […]

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Saudi Arabia’s ‘reformer’ King Abdullah dies

Categories: Homeland Security News

Surprise! Magnets used to plant drugs under cars from Mexico

Homeland Security News - Thu, 01/22/2015 - 22:51

Drug smugglers are turning “trusted travelers” into unwitting mules by placing containers with powerful magnets under their cars in Mexico and then recovering the illegal cargo far from the view of border authorities in the United States. One motorist spotted the containers while pumping gas after crossing into Southern California on Jan. 12 and thought […]

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Surprise! Magnets used to plant drugs under cars from Mexico

Categories: Homeland Security News

How Al Qaeda’s Biggest Enemy Took Over Yemen

Homeland Security News - Thu, 01/22/2015 - 22:49

Yemeni President Abdu Rabbu Mansour Hadi, his prime minister and entire government cabinet resigned en masse today, just 24 hours after Houthi rebels occupied the presidential compound in Sanaa. The resignations give unprecedented power to the Houthis, a Shiite minority from the country’s isolated northern highlands.The political crisis also opens the door to an all-out […]

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How Al Qaeda’s Biggest Enemy Took Over Yemen

Categories: Homeland Security News

ISIS’ Japanese hostage video raises new questions about ‘Jihadi John’

Homeland Security News - Wed, 01/21/2015 - 13:32

His voice, his posture and his threats are menacingly familiar. The black-clad ISIS militant shown in a video demanding a $200 million ransom to spare the lives of two Japanese citizens looks and sounds similar to the man who has appeared in at least five previous hostage videos. The knife-wielding masked man with a London […]

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ISIS’ Japanese hostage video raises new questions about ‘Jihadi John’

Categories: Homeland Security News

Undercover FBI sting nets alleged jihadist

Homeland Security News - Wed, 01/21/2015 - 13:27

The arrest of an Ohio man allegedly plotting an ISIS-inspired attack on the U.S. Capitol sent shockwaves across the country last week. 20-year-old Christopher Lee Cornell is now facing charges for attempting to kill U.S. government officials. Although he’s been labeled a lone wolf, he’s definitely not the only terror suspect caught up in an FBI […]

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Undercover FBI sting nets alleged jihadist

Categories: Homeland Security News