You are hereNews

News


Manganese concentrations in soil and settled dust in an area with historic ferroalloy production.

Paul J. Lioy, Ph.D. - Sun, 11/23/2014 - 15:00

Related Articles

Manganese concentrations in soil and settled dust in an area with historic ferroalloy production.

J Expo Sci Environ Epidemiol. 2014 Oct 22;

Authors: Pavilonis BT, Lioy PJ, Guazzetti S, Bostick BC, Donna F, Peli M, Zimmerman NJ, Bertrand P, Lucas E, Smith DR, Georgopoulos PG, Mi Z, Royce SG, Lucchini RG

Abstract
Ferroalloy production can release a number of metals into the environment, of which manganese (Mn) is of major concern. Other elements include lead, iron, zinc, copper, chromium, and cadmium. Mn exposure derived from settled dust and suspended aerosols can cause a variety of adverse neurological effects to chronically exposed individuals. To better estimate the current levels of exposure, this study quantified the metal levels in dust collected inside homes (n=85), outside homes (n=81), in attics (n=6), and in surface soil (n=252) in an area with historic ferroalloy production. Metals contained in indoor and outdoor dust samples were quantified using inductively coupled plasma optical emission spectroscopy, whereas attic and soil measurements were made with a X-ray fluorescence instrument. Mean Mn concentrations in soil (4600 μg/g) and indoor dust (870 μg/g) collected within 0.5 km of a plant exceeded levels previously found in suburban and urban areas, but did decrease outside 1.0 km to the upper end of background concentrations. Mn concentrations in attic dust were ~120 times larger than other indoor dust levels, consistent with historical emissions that yielded high airborne concentrations in the region. Considering the potential health effects that are associated with chronic Mn inhalation and ingestion exposure, remediation of soil near the plants and frequent, on-going hygiene indoors may decrease residential exposure and the likelihood of adverse health effects.Journal of Exposure Science and Environmental Epidemiology advance online publication, 22 October 2014; doi:10.1038/jes.2014.70.

PMID: 25335867 [PubMed - as supplied by publisher]

Categories: Publications from UCDPER Members

N (ω)-NITRO-N (ω')-SUBSTITUTED GUANIDINES: A SIMPLE CLASS OF NITRIC OXIDE SYNTHASE INHIBITORS.

Jeffrey D. Laskin, Ph.D. - Sun, 11/23/2014 - 15:00

Related Articles

N (ω)-NITRO-N (ω')-SUBSTITUTED GUANIDINES: A SIMPLE CLASS OF NITRIC OXIDE SYNTHASE INHIBITORS.

Mod Res Inflamm. 2014 May;3(2):48-58

Authors: Guillon CD, Wisnoski DD, Saxena J, Heindel ND, Heck DE, Wolff DJ, Laskin JD

Abstract
A series of N(ω)-nitro-N(ω')-substituted guanidines has been prepared as potential inhibitors of the human Nitric Oxide Synthase (NOS) isoforms. The reported utility of aminoguanidine and nitroarginine in iNOS inhibition points to a potential similar utility for analogs of nitro-guanidine. The compound library was tested against the three isoforms of Nitric Oxide Synthase (eNOS, iNOS and nNOS). Several candidates showed excellent activity and good selectivity for nNOS. One particular compound even demonstrated good selectivity for iNOS. The potential usefulness of such selective inhibitors is discussed.

PMID: 25360396 [PubMed - as supplied by publisher]

Categories: Publications from UCDPER Members

The World Health Organization (WHO) Recommends Vaccine Composition for the 2011-2012 Northern Hemisphere Influenza Season

PandemicFlu.gov - Sun, 11/23/2014 - 15:00

The World Health Organization (WHO) Recommends Vaccine Composition for the 2011-2012 Northern Hemisphere Influenza Season

Categories: Government Agency News